Pregabalin

What is Pregabalin?

Pregabalin is approved by the FDA and EMA for the treatment for neuropathic pain which is one of the most severe types of chronic pain. In addition, it can effectively treat fibromyalgia, restless leg syndrome and generalised anxiety disorder (GAD). Pregabalin became available in 2004 and belongs to a category of medications called analgesics. This tablet is marketed under the name Lyrica and can also be used with other medicines to provide fast acting pain relief.

What is Pregabalin Used For?

In 2007, pregabalin was approved for the treatment of fibromyalgia in patients over the age of 18. Fibromyalgia is a condition that can cause widespread pain in ligaments, tendons and muscles. It is often accompanied by sleeping difficulties, fatigue and depression. Patients with this condition experience exaggerated pain signals that intensify the feeling of pain in soft tissue and muscles.

Research suggests that pregabalin helps treat pain associated with fibromyalgia by reducing the activity of nerve signals. This relaxes excessively sensitive nerve cells and a patient with fibromyalgia experiences less pain as a result. In medical studies, some patients have reported notable improvements in their condition within only one week of treatment. Many people with fibromyalgia also benefit from improved sleep and function better in their daily lives with the use of this medicine.

Lyrica is also used to treat a variety of conditions ranging from neuropathic pain to generalised anxiety disorder (GAD) and more. The pharmacological profile of the tablet makes it possible to tackle a number of issues related to specific conditions. The tablet is frequently used to treat the following conditions:

• Neuropathic pain associated with diabetic peripheral neuropathy - this is pain that is caused by damaged nerves as a result of diabetes.
• Central neuropathic pain - this is pain that is caused by damaged nerves in the spinal cord and brain. This medication works by effectively blocking pain. It achieves this effect by altering pain messengers that travel from the brain to the spinal cord.
• Epilepsy - this medication reduces excessive electrical activity which is present in the brain due to epilepsy. Pregabalin slows down the impulses that cause seizures.
• Postherpetic neuralgia - this is chronic discomfort that develops in an area that was previously affected by shingles.
• Generalised anxiety disorder (GAD) - Lyrica tablets work here to stop the brain from releasing chemicals that lead to feelings of anxiety.
• Insomnia - up to 70 percent of patients with chronic pain suffer from a sleep disorder like insomnia. Pain and insomnia can feed each other and become a vicious cycle so it is important to find effective treatment. Thus, you can use pregabalin for sleep and treat sleeping difficulties associated with pain.

Pregabalin Dosage Information

The dose of this medication varies from one patient to another. Pregabalin tablets come in a variety of doses to ensure that patients have the required amount of Lyrica to effectively treat their relevant condition. The pregabalin dose ranges from 150mg to 600mg per day. This can be taken in 2 or 3 divided doses.

The tablet may be consumed with or without food. However, if you experience nausea or any other discomfort after taking it on an empty stomach, rather take it with some food thereafter. The recommended dose should always be followed and the medication should be taken at regular times each day. Exceeding the recommended dose can lead to adverse effects.

Using Pregabalin for Best Results

The recommended dosage of this medication depends on the condition being treated. It should be personalised for each patient. For best results, follow these recommended usage guidelines:

• A regular schedule should be followed when taking this medicine to ensure that the body becomes familiar with the treatment.
• It can take time for this medicine to work. In clinical studies, some patients respond well within 1 week of treatment and experience effective pain relief from various conditions.
• If you miss a dose, it may be taken as soon as you remember. However, if it is too close to the next dose, the missed dose should be skipped and the regular routine should be continued as usual.
• If you have taken this medication for a long-term period, do not stop using it suddenly as this can lead to withdrawal symptoms. If you would like to alter or discontinue your pregabalin dose or treatment, you should follow a "tapering off" process over at least one week.
• The tablet should be taken with a glass of water to ensure proper absorption.
• Do not crush, split or chew the tablet.
• Start treatment with the lowest effective dose and gradually increase it according to your individual response.

Pregabalin Side Effects

Side effects are rarely experienced and may occur if usage and dosage instructions are not carefully followed. Less than 10% of patients report the following pregabalin side effects:

• Dizziness
• Drowsiness or sleepiness
• Headache
• Lack of energy

If experienced, these common side effects can be self-managed. To reduce the likelihood of headache, make sure you avoid alcohol and drink plenty of water to keep well hydrated. Sleepiness usually wears off within one or two weeks as your body gets used to the medicine.

Pregabalin Benefits

This medication is beneficial for the treatment of various conditions. It reduces abnormal electrical activity in the central nervous system, blocks pain signals and decreases chemicals that cause anxiety. Essential benefits of Lyrica include:

• The treatment is well handled by most patients. Pregabalin side effects are rarely experienced and if encountered, they tend to be mild and can be self-managed.

• The tablet has a positive response and result rate with some patients noticing significant pain improvement in as little as 7 days post treatment.
• Patients can effortlessly buy pregabalin online as it is readily available on sites like ours.
• The medication has a high efficacy rate and can effectively treat chronic pain conditions.

• The tablet has a high safety profile making it one of the first pharmacotherapies to be considered for use in the management of neuropathic pain.
• This medication can be used for both long and short-term treatment plans.
• A patient does not need to have seizures in order to benefit from the anxiety and pain-relieving effects that this medication offers.
• Patients who use pregabalin for anxiety benefit from an overall treatment as the tablet helps treat the condition and symptoms that are linked to it.
• Patients can use pregabalin for sleep as well as specific pain management.

Because this medication has extremely powerful anxiolytic qualities that are much stronger than benzodiazepines such as Valium (diazepam), it is sometimes referred to as "New Valium" / "Valium on Steroids".

Pregabalin Warning

This medicine is used by a wide variety of people and has produced successful results in the majority of patients. However, there are some circumstances that contraindicate the use of this medication. Do not take it if you are allergic to pregabalin or other similar medicines. The safety and efficacy of this medicine has not been established in patients under the age of 18 so it should be avoided in this age group. Women who are pregnant, planning a pregnancy or breastfeeding should avoid the use of this medication.

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Pregabalin FAQ

How does pregabalin work after it is absorbed into the body?

This medication works by blocking pain sensations. It achieves this effect by interfering with pain signals that travel through the central nervous system. The tablet works in conjunction with normal metabolic processes to eliminate the feeling of pain and discomfort. This medication also prevents certain chemicals that cause anxiety from being released in the central nervous system.

What are the main conditions that this medication treats?

The medication is used to alleviate various conditions such as neuropathic pain, chronic neuropathic pain, postherpetic neuralgia, fibromyalgia, restless leg syndrome, epilepsy and anxiety.

Can I take pregabalin for more than 2 weeks?

Yes. This medication can be taken as a long or short-term treatment option. Upon discontinuation of treatment, the dose should be gradually reduced over a few days or weeks. This can help by decreasing the likelihood of withdrawal symptoms.

How will this tablet affect pregnancy and breast-feeding?

Lyrica should not be taken during pregnancy or by lactating mothers as it can cause side effects and affect the foetus or baby.

Can this medication be taken with or after alcohol consumption?

No. Alcohol use is not advised as it can negatively affect the efficacy of pregabalin tablets and cause more serious adverse effects.

Last Reviewed: 10th July 2024
Next Review Due: August 2025